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It is possible to manage 2FA for all PICS users from the User List, rather than have users manage it individually from their User Profiles.

Enforcing 2FA for All Users

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The next time the user logs in, they will be able to set up a new 2FA system.

Disabling 2FA

You can disable 2FA for your own account from the User Profile. To do this, go to the Two Factor Authentication section and select Disable Authenticator. This will deactivate any authenticator application you are currently using.